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Skincare Ingredient

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Adenosine

In Skincare: Is Adenosine Safe? Comedogenic Rating & Side Effects

Safety (overall safety)
1/5 — Very low risk
Irritancy (skin irritation)
1/5 — Very low risk

Safety Information

CIR-reviewed for cosmetic use; generally well tolerated with low irritation/sensitization risk at typical concentrations; comedogenicity data limited. The Cosmetic Ingredient Review Expert Panel concluded that adenosine is safe for use in cosmetics. Limited reports of adverse effects suggest it is well-tolerated by most skin types.

Quick Insights

At a glance

  • 01

    Adenosine may help to visibly reduce the appearance of wrinkles.

  • 02

    Adenosine exhibits soothing properties for skin.

  • 03

    Adenosine can contribute to a smoother skin surface.

Key Benefits

What Adenosine does for your skin

1 benefits
Soothing

Overview

Ingredient Profile

Adenosine is a naturally occurring compound found in the body, and studies suggest it can benefit skin by helping to soothe irritation and improve the appearance of wrinkles. Research, including a study by L’Oreal, indicates that even low concentrations (as low as 0.1%) can visibly reduce the appearance of fine lines and wrinkles, such as those around the eyes and between the brows. Recognized as safe for topical use in concentrations up to 1%, adenosine is a water-soluble ingredient suitable for various skin types.
Classifications
Plant Extracts

Role of Adenosine

Active Cosmetic Mechanisms

SKIN CONDITIONING

Skin Enhancer

Maintains skin in good condition and improves its feel

SCIENTIFIC ANALYSIS

// Evidence: Skin conditioning ingredients enhance appearance, texture, and health of skin through various mechanisms. This broad category encompasses emollients, humectants, occlusives, and other agents that improve skin feel, appearance, and function. May work by moisturizing, smoothing, softening, or protecting skin. Effects include improved tactile properties, enhanced barrier function, and better overall skin condition.

Products

containing Adenosine

6650 formulations
Liftactiv Supreme
Liftactiv Supreme
Vichy · moisturizer
Enjoy Super Active Airy Sun Stick SPF 50+ PA++++
Enjoy Super Active Airy Sun Stick SPF 50+ PA++++
SCINIC · sunscreen
REVITALIFT Hyaluronic Acid Plumping Gel Cleanser
REVITALIFT Hyaluronic Acid Plumping Gel Cleanser
L'Oreal · cleanser

References

Scientific sources

[1]

PubChem, Accessed May 2021, ePublication

[2]

Cosmetic Ingredient Review, September 2020, pages 1-38

[3]

Experimental Dermatology, August 2014, pages 553-554

[4]

Journal of Investigative Dermatology, August 2011, pages 526-546

[5]

International Journal of Cosmetic Science, December 2006, pages 447-451

[6]

British Journal of Pharmacology, October 2008, issue 4, pages 475-486

[7]

PloS One, May 2008 (ePublication)

[8]

>International Journal of Cosmetic Science, August 2006, pages 447-451

Semantic Analysis

Similar Ingredients

Ingredients with similar chemical profiles and skincare properties.

Frequently Asked Questions

Adenosine — common questions

What is Adenosine in skincare?

Adenosine is a skincare ingredient commonly used in cosmetic formulations.

What does Adenosine do? / Functions of Adenosine?

Common functions: SKIN CONDITIONING.

What is the comedogenic rating of Adenosine? / Is Adenosine comedogenic?

The comedogenic rating of Adenosine has not been established in our database.

Does it clog pores?
No Rating Available

Whether Adenosine clogs pores depends on the formulation and concentration.

Is Adenosine safe for skin?
1 1/5 — Very low risk

Adenosine has a safety rating of 1 out of 5. A rating of 1 means it is generally considered safe for most skin types. Note: CIR-reviewed for cosmetic use; generally well tolerated with low irritation/sensitization risk at typical concentrations; comedogenicity data limited. The Cosmetic Ingredient Review Expert Panel concl

Is Adenosine good for sensitive skin?
1 1/5 — Very low risk

Adenosine has an irritancy rating of 1 out of 5. A rating of 1 means it is generally well-tolerated.

What are the side effects of Adenosine in skincare?

Known considerations: CIR-reviewed for cosmetic use; generally well tolerated with low irritation/sensitization risk at typical concentrations; comedogenicity data limited. The Cosmetic Ingredient Review Expert Panel concluded that adenosine is safe for use in cosmetics. Limited reports of adverse effects suggest it is well-tolerated by most skin types.

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