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Skincare Ingredient

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Daidzein

In Skincare: Is Daidzein Safe? Comedogenic Rating & Side Effects

Safety (overall safety)
2/5 — Low risk

Safety Information

Isoflavone (often soy-derived); limited cosmetic-specific comedogenicity/irritancy data. The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that daidzein is safe in cosmetics as currently used, noting limited evidence of skin irritation or sensitization in available studies.

Quick Insights

At a glance

  • 01

    Daidzein is an antioxidant and isoflavone naturally found in soybeans.

  • 02

    Daidzein demonstrates a notable capacity to support skin resilience against environmental stressors.

  • 03

    As estrogen levels decline, daidzein may help improve signs of aging and textural irregularities.

  • 04

    Daidzein can contribute to improved skin hydration by supporting the natural production of hyaluronic acid.

Key Benefits

What Daidzein does for your skin

1 benefits
Anti-Aging

Overview

Ingredient Profile

Daidzein is a plant-derived antioxidant found in soybeans and other foods that helps protect skin from damage caused by UV light. Studies suggest it can reduce UVB-induced irritation and support the appearance of skin firmness. While absorption may be enhanced when combined with other isoflavones like genistein, daidzein demonstrates effectiveness in skincare formulations, particularly when delivered using skin-friendly ingredients like cyclodextrins. It is considered safe for topical use in concentrations typically ranging from 0.02% to 0.5%.
Classifications
Antioxidant
Plant Extracts

Role of Daidzein

Active Cosmetic Mechanisms

SKIN CONDITIONING - MISCELLANEOUS

General Skin Improver

Improves skin condition through various mechanisms

SCIENTIFIC ANALYSIS

// Evidence: This category includes skin conditioning ingredients working through mechanisms not classified as emollient, humectant, or occlusive. May include antioxidants providing protective conditioning, peptides supporting structural proteins, botanical extracts with various bioactive effects, or ingredients that improve skin condition through multiple simultaneous mechanisms. Provides diverse skin benefits that dont fit into other specific subcategories.

Products

containing Daidzein

2 formulations
Phytoestrogen Elasticity Renewal Serum
Phytoestrogen Elasticity Renewal Serum
Paula's Choice · serums-treatment
Phytoestrogen Elasticity Renewal Body Treatment
Phytoestrogen Elasticity Renewal Body Treatment
Paula's choice

References

Scientific sources

[1]

Phytotherapy Research, March 2020, pages 435–447

[2]

Journal of Drug Delivery Science and Technology, June 2019, pages 63–69

[3]

Molecules, December 2017, pages 1–11

[4]

Australasian Journal of Dermatology, February 2015, pages e7–e14

[5]

International Journal of Pharmaceutics, August 2008, pages 36–44

Semantic Analysis

Similar Ingredients

Ingredients with similar chemical profiles and skincare properties.

Frequently Asked Questions

Daidzein — common questions

What is Daidzein in skincare?

Daidzein is a skincare ingredient commonly used in cosmetic formulations.

What does Daidzein do? / Functions of Daidzein?

Common functions: SKIN CONDITIONING - MISCELLANEOUS.

What is the comedogenic rating of Daidzein? / Is Daidzein comedogenic?

The comedogenic rating of Daidzein has not been established in our database.

Does it clog pores?
No Rating Available

Whether Daidzein clogs pores depends on the formulation and concentration.

Is Daidzein safe for skin?
2 2/5 — Low risk

Daidzein has a safety rating of 2 out of 5. A rating of 2 means it is generally considered safe for most skin types. Note: Isoflavone (often soy-derived); limited cosmetic-specific comedogenicity/irritancy data. The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that daidzein is safe in cosmetics as currently

Is Daidzein good for sensitive skin?

Daidzein tolerance on sensitive skin varies by individual.

What are the side effects of Daidzein in skincare?

Known considerations: Isoflavone (often soy-derived); limited cosmetic-specific comedogenicity/irritancy data. The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that daidzein is safe in cosmetics as currently used, noting limited evidence of skin irritation or sensitization in available studies.

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