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Skincare Ingredient

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Glycerin

In Skincare: Is Glycerin Safe? Comedogenic Rating & Side Effects

Comedogenicity (pore clogging)
1/5 — Very low risk
Safety (overall safety)
1/5 — Very low risk
Irritancy (skin irritation)
1/5 — Very low risk

Safety Information

Well-studied humectant; CIR and broad cosmetic use support very low irritation/sensitization and non-comedogenicity for most users. The Cosmetic Ingredient Review (CIR) Expert Panel has deemed glycerin safe for use in cosmetics, and it is generally recognized as safe (GRAS) by the FDA when used in personal care products.

Quick Insights

At a glance

  • 01

    Glycerin is a humectant naturally found in skin.

  • 02

    Glycerin helps the skin maintain its moisture balance by drawing water to it.

  • 03

    Glycerin contributes to a healthy appearance and feel of the skin.

Key Benefits

What Glycerin does for your skin

2 benefits
Hydration
Anti-Aging

Overview

Ingredient Profile

Glycerin is a highly effective humectant, meaning it draws moisture to the skin and helps maintain hydration. Naturally found in skin lipids, glycerin can be derived from both natural and synthetic sources, with the latter typically providing a highly purified form for skincare. When used in typical concentrations (up to 5%) within formulations containing emollients or oils, glycerin supports a healthy skin barrier and defends against dryness. While pure glycerin can potentially draw moisture from deeper layers in very dry climates, this is not a concern when used in skincare products.
Classifications
Humectant
Texture Enhancer
Solvent

Data & Research

Scientific Facts

Glycerin plays a role in the body by being involved in the synthesis of triglycerides and phospholipids within the liver and fat tissues. During energy metabolism, glycerol and fatty acids are released into the bloodstream when the body utilizes stored fat reserves. It’s a widely utilized ingredient in both the food and pharmaceutical industries, serving as a humectant, solvent, sweetener, and preservative in foods. Glycerin is frequently added to dried fruits to maintain their texture and prevent brittleness, and it contributes to the smooth consistency of ice cream and forms the base of toothpaste. In medical settings, glycerol is sometimes administered intravenously to reduce intracranial pressure in conditions such as stroke, meningitis, encephalitis, and central nervous system trauma.

Common Uses

Formulation in Glycerin

Glycerin is a common ingredient in cosmetics and personal care products, including soaps, toothpaste, shaving cream, and skin/hair care formulations. It functions primarily as a humectant – meaning it draws moisture to the product and helps prevent dryness. It’s also used as a fragrance ingredient, a denaturant, a hair conditioning agent, and in oral care products. According to data from the 2019 U.S. FDA Voluntary Cosmetic Registration Program (VCRP), glycerin was the third most frequently used ingredient in cosmetics, appearing in over 23,000 products across categories like eye products, lipsticks, hair dyes, bath soaps, skin care, sunscreens, and baby products. A 2014 Personal Care Products Council (PCPC) survey indicated that glycerin concentrations could reach up to 99.4% in some skin cleaning products.

Role of Glycerin

Active Cosmetic Mechanisms

DENATURANT

Alcohol Treatment Agent

Makes alcohol undrinkable in cosmetic products

SCIENTIFIC ANALYSIS

// Evidence: Denaturants are added to ethanol to render it unfit for consumption while maintaining cosmetic functionality. Common denaturants include denatonium benzoate (extremely bitter), diethyl phthalate, and tert-butyl alcohol. This allows manufacturers to use tax-free specially denatured alcohol. Denaturants must meet specific regulatory formulations with precise ratios.

FRAGRANCE

Scent Provider

Adds pleasant scent to cosmetic products

SCIENTIFIC ANALYSIS

// Evidence: Fragrance ingredients provide aromatic appeal through essential oils, aroma chemicals, and natural extracts. These volatile compounds interact with olfactory receptors creating scent perception. Fragrance design considers top notes (high volatility), middle notes (moderate volatility), and base notes (low volatility) for scent development over time. Must consider stability, allergen content, and regulatory compliance.

HAIR CONDITIONING

Hair Softener

Improves hair manageability, softness, and appearance

SCIENTIFIC ANALYSIS

// Evidence: Hair conditioning ingredients smooth the cuticle, reduce frizz, and add shine through cationic surfactants (behentrimonium chloride), silicones (dimethicone, amodimethicone), natural oils, and proteins. These deposit on negatively charged damaged sites, neutralizing charge, filling surface irregularities, and providing lubrication. Mechanism involves electrostatic attraction, film formation, and surface smoothing.

HUMECTANT

Moisture Magnet

Attracts and retains moisture in skin and hair

SCIENTIFIC ANALYSIS

// Evidence: Humectant ingredients draw water from the environment and deeper skin layers through hygroscopic properties. Common humectants include glycerin, propylene glycol, hyaluronic acid, urea, and alpha-hydroxy acids. These contain multiple hydroxyl groups or other hydrophilic functional groups that form hydrogen bonds with water molecules. Mechanism involves attracting water to the stratum corneum, reducing transepidermal water loss, and increasing skin hydration.

ORAL CARE

Dental Health Agent

Maintains or improves oral hygiene and dental health

SCIENTIFIC ANALYSIS

// Evidence: Oral care ingredients support dental health through fluoride compounds (stannous fluoride, sodium fluoride for remineralization), antimicrobials (triclosan, CPC), abrasives (silica for cleaning), and desensitizing agents (potassium nitrate, strontium chloride). Mechanisms include strengthening enamel through fluorapatite formation, reducing bacteria, removing stains, and blocking dentinal tubules. Must meet specific efficacy and safety standards.

PERFUMING

Fragrance Provider

Provides fragrance to enhance product appeal

SCIENTIFIC ANALYSIS

// Evidence: Perfuming ingredients add pleasant scents through complex mixtures of natural essential oils, aroma chemicals, and synthetic compounds. These volatile molecules evaporate and interact with olfactory receptors. Perfume construction uses top notes (citrus, herbs - high volatility), middle notes (floral, spice - moderate volatility), and base notes (woods, musks - low volatility) creating evolving scent profile. Must consider stability, allergen declaration, and IFRA compliance.

SKIN CONDITIONING - HUMECTANT

Hydration Booster

Draws moisture into skin for hydration

SCIENTIFIC ANALYSIS

// Evidence: Humectant-type skin conditioners attract and bind water to increase skin hydration. Key ingredients include glycerin, hyaluronic acid, sodium PCA, urea, and propylene glycol. These hygroscopic molecules form hydrogen bonds with water from dermis and environment, increasing water content in stratum corneum. The mechanism involves osmotic gradient creation and water binding through hydrophilic functional groups. Results in plumping effect and improved skin flexibility.

SKIN PROTECTING

Defensive Shield

Shields skin from external aggressors and damage

SCIENTIFIC ANALYSIS

// Evidence: Skin protecting ingredients defend against environmental stressors, irritants, and damage through barrier enhancement, antioxidant activity, anti-pollution effects, or physical barriers. Include dimethicone (barrier), allantoin (soothing protectant), zinc oxide (physical protectant), and film-formers. Mechanisms vary: forming protective films, neutralizing oxidative stress, chelating pollutants, strengthening barrier function. Used in protective creams, barrier treatments, and defensive skincare against urban pollution, extreme weather.

SOLVENT

Ingredient Dissolver

Dissolves other ingredients to create uniform formulations

SCIENTIFIC ANALYSIS

// Evidence: Solvents dissolve, dilute, or disperse other ingredients creating homogeneous solutions. Water is universal solvent for hydrophilic ingredients. Organic solvents include ethanol (dissolves fragrances, some actives), propylene glycol, and glycerin. Selection based on polarity matching between solvent and solute. Mechanism involves disrupting intermolecular forces in solute and surrounding with solvent molecules. Critical for maintaining ingredient solubility and product stability.

VISCOSITY CONTROLLING

Thickness Regulator

Adjusts product thickness and flow properties

SCIENTIFIC ANALYSIS

// Evidence: Viscosity controlling ingredients modify product flow characteristics through thickening or thinning. Thickeners include natural gums (xanthan, guar), synthetic polymers (carbomers, acrylates), and inorganic thickeners (silica, clays). Mechanism varies: polymer chain entanglement, hydrogen bonding networks, particle association, or swelling. Rheology modifiers create desired texture, prevent separation, control application properties, and affect sensory perception. Can produce Newtonian (constant viscosity) or non-Newtonian (shear-thinning, thixotropic) flow behavior.

Products

containing Glycerin

66495 formulations
Pore Tightening Mask
Pore Tightening Mask
SHANGPREE
Good Morning Cream
Good Morning Cream
The Vegan Glow
Advanced Night Repair Concentrated Recovery PowerFoil Mask
Advanced Night Repair Concentrated Recovery PowerFoil Mask
Estee Lauder

References

Scientific sources

[1]

Journal of Pharmaceutical Investigation, March 2021, pages 223-231

[2]

International Journal of Toxicology, November/December 2019, Volume 38, Supplement 3, pages 6S-22S

[3]

International Journal of Cosmetic Science, August 2016, ePublication

[4]

British Journal of Dermatology, July 2008, pages 23-34

[5]

Journal of Cosmetic Dermatology, June 2007, pages 75-82

[6]

Proceedings of the National Academy of Sciences, June 2003, pages 7,360-7,365

Semantic Analysis

Similar Ingredients

Ingredients with similar chemical profiles and skincare properties.

Frequently Asked Questions

Glycerin — common questions

What is Glycerin in skincare?

Glycerin, also known as glycerol, is a naturally occurring alcohol compound found in animal, plant, and human tissues. It can be derived from natural sources like soybeans, cane sugar, or corn syrup, or produced synthetically.

What does Glycerin do? / Functions of Glycerin?

Common functions: DENATURANT, FRAGRANCE, HAIR CONDITIONING, HUMECTANT, ORAL CARE, PERFUMING.

What is the comedogenic rating of Glycerin? / Is Glycerin comedogenic?
1 1/5 — Very low risk

Glycerin has a comedogenic rating of 1 out of 5. A rating of 1 means it is unlikely to clog pores.

Does it clog pores?
Unlikely to Clog Pores

Glycerin is unlikely to clog pores (rating 1/5).

Is Glycerin safe for skin?
1 1/5 — Very low risk

Glycerin has a safety rating of 1 out of 5. A rating of 1 means it is generally considered safe for most skin types. Note: Well-studied humectant; CIR and broad cosmetic use support very low irritation/sensitization and non-comedogenicity for most users. The Cosmetic Ingredient Review (CIR) Expert Panel has deemed glyceri

Is Glycerin good for sensitive skin?
1 1/5 — Very low risk

Glycerin has an irritancy rating of 1 out of 5. A rating of 1 means it is generally well-tolerated.

What are the side effects of Glycerin in skincare?

Known considerations: Well-studied humectant; CIR and broad cosmetic use support very low irritation/sensitization and non-comedogenicity for most users. The Cosmetic Ingredient Review (CIR) Expert Panel has deemed glycerin safe for use in cosmetics, and it is generally recognized as safe (GRAS) by the FDA when used in personal care products.

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