Skincare Ingredient
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Palmitoyl Pentapeptide-4
In Skincare: Is Palmitoyl Pentapeptide-4 Safe? Comedogenic Rating & Side Effects
Safety Information
Quick Insights
At a glance
- 01
Palmitoyl Pentapeptide-4 is a synthetic peptide designed to mimic naturally occurring signaling molecules.
- 02
This ingredient may improve the appearance of skin firmness and elasticity by supporting collagen and elastin production.
- 03
Palmitoyl Pentapeptide-4 may contribute to skin hydration by influencing hyaluronic acid levels.
- 04
The CIR Expert Panel has determined Palmitoyl Pentapeptide-4 to be safe as used in cosmetic formulations.
Key Benefits
What Palmitoyl Pentapeptide-4 does for your skin
Overview
Ingredient Profile
Role of Palmitoyl Pentapeptide-4
Active Cosmetic Mechanisms
SKIN CONDITIONING
Skin EnhancerMaintains skin in good condition and improves its feel
SCIENTIFIC ANALYSIS
// Evidence: Skin conditioning ingredients enhance appearance, texture, and health of skin through various mechanisms. This broad category encompasses emollients, humectants, occlusives, and other agents that improve skin feel, appearance, and function. May work by moisturizing, smoothing, softening, or protecting skin. Effects include improved tactile properties, enhanced barrier function, and better overall skin condition.
Products
containing Palmitoyl Pentapeptide-4
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References
Scientific sources
PubChem, Website, Accessed January 2026
Cosmetic Ingredient Review, Website, Accessed January 2026
SpecialChem, Website, Accessed January 2026
Authorea, August 2025, pages 1-10
Biomolecules, January 2025, pages 1-30
Cosmetics, August 2023, pages 1-18
Journal of Clinical and Aesthetic Dermatology, February 2023, pages 37-43
Similar Ingredients
Ingredients with similar chemical profiles and skincare properties.
Frequently Asked Questions
Palmitoyl Pentapeptide-4 — common questions
What is Palmitoyl Pentapeptide-4 in skincare?
Lysine, synthetic pentapeptide with serine, and threonine, hexadecanoyl derivatives
What does Palmitoyl Pentapeptide-4 do? / Functions of Palmitoyl Pentapeptide-4?
Common functions: SKIN CONDITIONING.
What is the comedogenic rating of Palmitoyl Pentapeptide-4? / Is Palmitoyl Pentapeptide-4 comedogenic?
The comedogenic rating of Palmitoyl Pentapeptide-4 has not been established in our database.
Does it clog pores?
Whether Palmitoyl Pentapeptide-4 clogs pores depends on the formulation and concentration.
Is Palmitoyl Pentapeptide-4 safe for skin?
Palmitoyl Pentapeptide-4 has a safety rating of 2 out of 5. A rating of 2 means it is generally considered safe for most skin types. Note: Generally low risk peptide used in anti-aging products with low irritation or sensitization reported in typical cosmetic use. The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated Palmitoyl
Is Palmitoyl Pentapeptide-4 good for sensitive skin?
Palmitoyl Pentapeptide-4 tolerance on sensitive skin varies by individual.
What are the side effects of Palmitoyl Pentapeptide-4 in skincare?
Known considerations: Generally low risk peptide used in anti-aging products with low irritation or sensitization reported in typical cosmetic use. The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated Palmitoyl Pentapeptide-4 and concluded it is safe for use in cosmetics at concentrations up to 10%.