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Skincare Ingredient

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Phytosphingosine

In Skincare: Is Phytosphingosine Safe? Comedogenic Rating & Side Effects

Comedogenicity (pore clogging)
1/5 — Very low risk
Safety (overall safety)
2/5 — Low risk
Irritancy (skin irritation)
2/5 — Low risk

Safety Information

Phytosphingosine is generally considered safe for topical use, with the Cosmetic Ingredient Review (CIR) Expert Panel concluding it is safe in the present practices of use. Limited reports of mild irritation have been noted, and it is not expected to be a significant sensitization risk.

Quick Insights

At a glance

  • 01

    Phytosphingosine is a lipid naturally present in the upper layers of healthy skin.

  • 02

    As a component of the skin’s natural moisturizing factor (NMF), phytosphingosine contributes to hydration.

  • 03

    Phytosphingosine helps to restore and support the skin’s protective barrier function.

  • 04

    Phytosphingosine can provide a soothing effect on the skin.

Key Benefits

What Phytosphingosine does for your skin

2 benefits
Anti-Aging
Hydration

Overview

Ingredient Profile

Phytosphingosine is a naturally occurring fatty alcohol found in the skin's outer layer that plays a vital role in maintaining the skin’s natural moisturizing factor and is a component of ceramides, which contribute to skin structure. In skincare, it helps support the skin barrier and may offer soothing benefits, potentially reducing redness and sensitivity. Considered safe for cosmetic use at low concentrations (typically below 1%), phytosphingosine is a well-tolerated ingredient that supports healthy skin.
Classifications
Emollient

Role of Phytosphingosine

Active Cosmetic Mechanisms

HAIR CONDITIONING

Hair Softener

Improves hair manageability, softness, and appearance

SCIENTIFIC ANALYSIS

// Evidence: Hair conditioning ingredients smooth the cuticle, reduce frizz, and add shine through cationic surfactants (behentrimonium chloride), silicones (dimethicone, amodimethicone), natural oils, and proteins. These deposit on negatively charged damaged sites, neutralizing charge, filling surface irregularities, and providing lubrication. Mechanism involves electrostatic attraction, film formation, and surface smoothing.

SKIN CONDITIONING

Skin Enhancer

Maintains skin in good condition and improves its feel

SCIENTIFIC ANALYSIS

// Evidence: Skin conditioning ingredients enhance appearance, texture, and health of skin through various mechanisms. This broad category encompasses emollients, humectants, occlusives, and other agents that improve skin feel, appearance, and function. May work by moisturizing, smoothing, softening, or protecting skin. Effects include improved tactile properties, enhanced barrier function, and better overall skin condition.

Products

containing Phytosphingosine

1994 formulations
Bariéderm Cleansing Cica-Gel
Bariéderm Cleansing Cica-Gel
Uriage · cleanser
Renewing SA Cleanser
Renewing SA Cleanser
CeraVe · cleanser
Moisturizing Cream
Moisturizing Cream
CeraVe · moisturizer

References

Scientific sources

[1]

Journal of Dermatological Science, January 2020, Volume 97, Issue 1, pages 2-8

[2]

Archives of Dermatological Research, December 2017, Volume 309, Issue 10, pages 795-803

[3]

Biochimica et Biophysica Acta: Biomembranes, May 2017, Volume 1859, Issue 5, pages 824-834

[4]

International Journal of Cosmetic Science, June 2007, Volume 29, Issue 3, pages 181-190

[5]

Molecular Medicine, January-March 2006, pages 17-24

[6]

Journal of Investigative Dermatology, October 2003, issue 5, pages 1135–1137

Semantic Analysis

Similar Ingredients

Ingredients with similar chemical profiles and skincare properties.

Frequently Asked Questions

Phytosphingosine — common questions

What is Phytosphingosine in skincare?

Phytosphingosine is a skincare ingredient commonly used in cosmetic formulations.

What does Phytosphingosine do? / Functions of Phytosphingosine?

Common functions: HAIR CONDITIONING, SKIN CONDITIONING.

What is the comedogenic rating of Phytosphingosine? / Is Phytosphingosine comedogenic?
1 1/5 — Very low risk

Phytosphingosine has a comedogenic rating of 1 out of 5. A rating of 1 means it is unlikely to clog pores.

Does it clog pores?
Unlikely to Clog Pores

Phytosphingosine is unlikely to clog pores (rating 1/5).

Is Phytosphingosine safe for skin?
2 2/5 — Low risk

Phytosphingosine has a safety rating of 2 out of 5. A rating of 2 means it is generally considered safe for most skin types. Note: Phytosphingosine is generally considered safe for topical use, with the Cosmetic Ingredient Review (CIR) Expert Panel concluding it is safe in the present practices of use. Limited reports of mild irr

Is Phytosphingosine good for sensitive skin?
2 2/5 — Low risk

Phytosphingosine has an irritancy rating of 2 out of 5. A rating of 2 means it is generally well-tolerated.

What are the side effects of Phytosphingosine in skincare?

Known considerations: Phytosphingosine is generally considered safe for topical use, with the Cosmetic Ingredient Review (CIR) Expert Panel concluding it is safe in the present practices of use. Limited reports of mild irritation have been noted, and it is not expected to be a significant sensitization risk.

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