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Skincare Ingredient

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Squalane

In Skincare: Is Squalane Safe? Comedogenic Rating & Side Effects

Comedogenicity (pore clogging)
1/5 — Very low risk
Safety (overall safety)
1/5 — Very low risk
Irritancy (skin irritation)
1/5 — Very low risk

Safety Information

Generally well-tolerated emollient; CIR and EWG note low hazard with no evidence of carcinogenicity or endocrine disruption in cosmetic use; rare individual allergy possible. Squalane has a comedogenicity rating of 1 and an irritancy rating of 1, indicating minimal risk of clogged pores or skin irritation.

Quick Insights

At a glance

  • 01

    Squalane helps to minimize water loss from the skin’s surface.

  • 02

    Squalane can improve the feel of skin by restoring suppleness.

  • 03

    Squalane contributes to a stronger skin barrier.

  • 04

    Due to its texture, squalane provides hydration without leaving a greasy feel.

Key Benefits

What Squalane does for your skin

2 benefits
Hydration
Anti-Aging

Overview

Ingredient Profile

Squalane is a lightweight, plant-derived emollient that helps hydrate and soften skin by preventing moisture loss. Derived from sources like olive, rice bran, or wheat germ oils, it's a stable form of squalene, a naturally occurring component of skin sebum. Squalane also provides antioxidant protection and can help strengthen the skin's barrier, contributing to a more resilient complexion. Decades of use and safety evaluations confirm squalane is considered safe for topical skincare application at various concentrations.
Classifications
Emollient
Antioxidant

Role of Squalane

Active Cosmetic Mechanisms

HAIR CONDITIONING

Hair Softener

Improves hair manageability, softness, and appearance

SCIENTIFIC ANALYSIS

// Evidence: Hair conditioning ingredients smooth the cuticle, reduce frizz, and add shine through cationic surfactants (behentrimonium chloride), silicones (dimethicone, amodimethicone), natural oils, and proteins. These deposit on negatively charged damaged sites, neutralizing charge, filling surface irregularities, and providing lubrication. Mechanism involves electrostatic attraction, film formation, and surface smoothing.

REFATTING

Lipid Restorer

Replenishes natural oils and lipids removed during cleansing

SCIENTIFIC ANALYSIS

// Evidence: Refatting ingredients restore the lipid barrier depleted by surfactants through oils, lipids, and emollients that deposit during rinsing. These include plant oils, fatty alcohols, lanolin, and ceramides. The mechanism involves replenishing intercellular lipids and surface sebum, preventing the tight, dry feeling from harsh cleansing. Particularly important in syndets and gentle cleansers to maintain barrier integrity while cleansing.

SKIN CONDITIONING

Skin Enhancer

Maintains skin in good condition and improves its feel

SCIENTIFIC ANALYSIS

// Evidence: Skin conditioning ingredients enhance appearance, texture, and health of skin through various mechanisms. This broad category encompasses emollients, humectants, occlusives, and other agents that improve skin feel, appearance, and function. May work by moisturizing, smoothing, softening, or protecting skin. Effects include improved tactile properties, enhanced barrier function, and better overall skin condition.

SKIN CONDITIONING - EMOLLIENT

Skin Softener

Softens and smooths skin by filling gaps between cells

SCIENTIFIC ANALYSIS

// Evidence: Emollient ingredients create smooth, soft skin by filling spaces between corneocytes in stratum corneum. These include esters (isopropyl palmitate), oils (jojoba, argan), fatty alcohols, and silicones. The mechanism involves spreading on skin surface, filling microscopic irregularities, and creating lubricious film. Effects are immediate tactile improvement and visual smoothing. Emolliency measured by spreading coefficient and skin feel assessments.

Products

containing Squalane

11007 formulations
Deep Renewal Lip Balm
Deep Renewal Lip Balm
Blistex · eye-lip-care
Sekkisei Clear Wellness UV Sunscreen Essence Gel SPF 50+ PA++++
Sekkisei Clear Wellness UV Sunscreen Essence Gel SPF 50+ PA++++
Kose Cosmeport · sunscreen
M Perfect Cover BB Cream SPF 42
M Perfect Cover BB Cream SPF 42
Missha · moisturizer

References

Scientific sources

[1]

Cosmetics Ingredient Review, 2019, ePublication

[2]

ACS Open, July 2017, pages 3,989–3,996

[3]

Indian Journal of Dermatology, May-June 2016, pages 279-297

[4]

The Journal of Clinical and Aesthetic Dermatology, June 2014, pages 25-32

[5]

Journal of Cosmetic Science, January-February 2013, pages 59-66

[6]

Advances in Food and Nutrition Research, 2012, pages 223-233

[7]

Molecules, January 2009, pages 540-554

[8]

Journal of Investigative Dermatology, November 2006, pages 2,430-2,437

[9]

Free Radical Research, April 2002, pages 471-477

Semantic Analysis

Similar Ingredients

Ingredients with similar chemical profiles and skincare properties.

Frequently Asked Questions

Squalane — common questions

What is Squalane in skincare?

Squalane is a skincare ingredient commonly used in cosmetic formulations.

What does Squalane do? / Functions of Squalane?

Common functions: HAIR CONDITIONING, REFATTING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT.

What is the comedogenic rating of Squalane? / Is Squalane comedogenic?
1 1/5 — Very low risk

Squalane has a comedogenic rating of 1 out of 5. A rating of 1 means it is unlikely to clog pores.

Does it clog pores?
Unlikely to Clog Pores

Squalane is unlikely to clog pores (rating 1/5).

Is Squalane safe for skin?
1 1/5 — Very low risk

Squalane has a safety rating of 1 out of 5. A rating of 1 means it is generally considered safe for most skin types. Note: Generally well-tolerated emollient; CIR and EWG note low hazard with no evidence of carcinogenicity or endocrine disruption in cosmetic use; rare individual allergy possible. Squalane has a comedogeni

Is Squalane good for sensitive skin?
1 1/5 — Very low risk

Squalane has an irritancy rating of 1 out of 5. A rating of 1 means it is generally well-tolerated.

What are the side effects of Squalane in skincare?

Known considerations: Generally well-tolerated emollient; CIR and EWG note low hazard with no evidence of carcinogenicity or endocrine disruption in cosmetic use; rare individual allergy possible. Squalane has a comedogenicity rating of 1 and an irritancy rating of 1, indicating minimal risk of clogged pores or skin irritation.

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