Skincare Ingredient
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Ascorbyl Tetraisopalmitate
In Skincare: Is Ascorbyl Tetraisopalmitate Safe? Comedogenic Rating & Side Effects
Safety Information
Quick Insights
At a glance
- 01
Ascorbyl tetraisopalmitate is an oil-soluble derivative of vitamin C (ascorbic acid).
- 02
This ingredient may help protect skin from environmental damage that contributes to signs of aging.
- 03
Ascorbyl tetraisopalmitate supports a firmer skin structure.
- 04
Also known as ATIP, this ingredient is also marketed under the name tetrahexyldecyl ascorbate (THD Ascorbate).
Key Benefits
What Ascorbyl Tetraisopalmitate does for your skin
Overview
Ingredient Profile
Role of Ascorbyl Tetraisopalmitate
Active Cosmetic Mechanisms
ANTIOXIDANT
Anti-Aging ProtectorProtects products and skin from oxidative damage and aging
SCIENTIFIC ANALYSIS
// Evidence: Antioxidants prevent or delay oxidation by donating electrons to free radicals, chelating pro-oxidant metals, or regenerating other antioxidants. Mechanisms include direct radical scavenging (vitamin E, vitamin C, BHT, BHA), metal chelation (EDTA), or enzymatic action. On skin, they neutralize reactive oxygen species (ROS) generated by UV radiation and pollution, preventing lipid peroxidation and DNA damage.
SKIN CONDITIONING - EMOLLIENT
Skin SoftenerSoftens and smooths skin by filling gaps between cells
SCIENTIFIC ANALYSIS
// Evidence: Emollient ingredients create smooth, soft skin by filling spaces between corneocytes in stratum corneum. These include esters (isopropyl palmitate), oils (jojoba, argan), fatty alcohols, and silicones. The mechanism involves spreading on skin surface, filling microscopic irregularities, and creating lubricious film. Effects are immediate tactile improvement and visual smoothing. Emolliency measured by spreading coefficient and skin feel assessments.
Products
containing Ascorbyl Tetraisopalmitate
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References
Scientific sources
International Journal of Toxicology
August 2022
pages 57S-75S
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Frequently Asked Questions
Ascorbyl Tetraisopalmitate — common questions
What is Ascorbyl Tetraisopalmitate in skincare?
Ascorbyl Tetraisopalmitate is a skincare ingredient commonly used in cosmetic formulations.
What does Ascorbyl Tetraisopalmitate do? / Functions of Ascorbyl Tetraisopalmitate?
Common functions: ANTIOXIDANT, SKIN CONDITIONING - EMOLLIENT.
What is the comedogenic rating of Ascorbyl Tetraisopalmitate? / Is Ascorbyl Tetraisopalmitate comedogenic?
Ascorbyl Tetraisopalmitate has a comedogenic rating of 2 out of 5. A rating of 2 means it is unlikely to clog pores.
Does it clog pores?
Ascorbyl Tetraisopalmitate is unlikely to clog pores (rating 2/5).
Is Ascorbyl Tetraisopalmitate safe for skin?
Ascorbyl Tetraisopalmitate has a safety rating of 2 out of 5. A rating of 2 means it is generally considered safe for most skin types. Note: Fat-soluble vitamin C derivative; CIR/EWG indicate generally low hazard with low irritation/sensitization potential; may be mildly comedogenic in acne-prone users depending on formulation concentratio
Is Ascorbyl Tetraisopalmitate good for sensitive skin?
Ascorbyl Tetraisopalmitate has an irritancy rating of 1 out of 5. A rating of 1 means it is generally well-tolerated.
What are the side effects of Ascorbyl Tetraisopalmitate in skincare?
Known considerations: Fat-soluble vitamin C derivative; CIR/EWG indicate generally low hazard with low irritation/sensitization potential; may be mildly comedogenic in acne-prone users depending on formulation concentration. It is considered safe for topical use at concentrations typically found in cosmetic products. Limited safety data is available for long-term or high-concentration use.