Skincare Ingredient
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Gluconolactone
In Skincare: Is Gluconolactone Safe? Comedogenic Rating & Side Effects
Safety Information
Quick Insights
At a glance
- 01
Gluconolactone is a polyhydroxy acid (PHA) belonging to a class of exfoliating ingredients.
- 02
Compared to alpha hydroxy acids (AHAs), gluconolactone exhibits a larger molecular size.
- 03
Some individuals may find gluconolactone to be slightly less sensitizing than alpha hydroxy acids (AHAs).
- 04
Gluconolactone functions as an antioxidant, helping to protect skin from free radical damage.
- 05
Gluconolactone contributes to improved surface strength of the skin.
Key Benefits
What Gluconolactone does for your skin
Overview
Ingredient Profile
Data & Research
Scientific Facts
Common Uses
Formulation in Gluconolactone
Role of Gluconolactone
Active Cosmetic Mechanisms
CHELATING
Metal Ion BinderBinds metal ions to improve product stability
SCIENTIFIC ANALYSIS
// Evidence: Chelating agents form stable, water-soluble complexes with polyvalent metal ions (Fe²⁺, Fe³⁺, Cu²⁺, Ca²⁺, Mg²⁺) through coordinate covalent bonds. Common chelators include EDTA, citric acid, phytic acid, and gluconates. The mechanism involves multidentate ligands wrapping around metal ions, preventing them from catalyzing oxidation reactions, causing discoloration, or reducing preservative efficacy.
SKIN CONDITIONING
Skin EnhancerMaintains skin in good condition and improves its feel
SCIENTIFIC ANALYSIS
// Evidence: Skin conditioning ingredients enhance appearance, texture, and health of skin through various mechanisms. This broad category encompasses emollients, humectants, occlusives, and other agents that improve skin feel, appearance, and function. May work by moisturizing, smoothing, softening, or protecting skin. Effects include improved tactile properties, enhanced barrier function, and better overall skin condition.
Products
containing Gluconolactone
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References
Scientific sources
Clinics in Dermatology, September-October 2009, pages 495-501
Cutis, February 2004, Supplement, pages 3-13
Similar Ingredients
Ingredients with similar chemical profiles and skincare properties.
Frequently Asked Questions
Gluconolactone — common questions
What is Gluconolactone in skincare?
Gluconolactone (also known as glucono delta-lactone) is a derivative of Gluconic Acid. It’s produced by removing water from Gluconic Acid, which itself is a carboxylic acid. Salts of Gluconic Acid – including Barium Gluconate, Calcium Gluconate, Cobalt Gluconate, Copper Gluconate, Ferrous Gluconate, Lithium Gluconate, Magnesium Gluconate, Manganese Gluconate, Potassium Gluconate, and Zinc Gluconate – are also used in cosmetic formulations.
What does Gluconolactone do? / Functions of Gluconolactone?
Common functions: CHELATING, SKIN CONDITIONING.
What is the comedogenic rating of Gluconolactone? / Is Gluconolactone comedogenic?
Gluconolactone has a comedogenic rating of 1 out of 5. A rating of 1 means it is unlikely to clog pores.
Does it clog pores?
Gluconolactone is unlikely to clog pores (rating 1/5).
Is Gluconolactone safe for skin?
Gluconolactone has a safety rating of 1 out of 5. A rating of 1 means it is generally considered safe for most skin types. Note: Polyhydroxy acid (PHA) exfoliant/humectant; generally well tolerated and non-comedogenic; may cause mild stinging/irritation in very sensitive or compromised skin at higher leave-on levels.
Is Gluconolactone good for sensitive skin?
Gluconolactone has an irritancy rating of 2 out of 5. A rating of 2 means it is generally well-tolerated.
What are the side effects of Gluconolactone in skincare?
Known considerations: Polyhydroxy acid (PHA) exfoliant/humectant; generally well tolerated and non-comedogenic; may cause mild stinging/irritation in very sensitive or compromised skin at higher leave-on levels.