SkinWis
SkinWis Scientific

Skincare Ingredient

Sign in to save this ingredient

Save ingredients to your skin profile and we'll use them when you look up products — instantly flagging what's reactive, neutral, or works well for your skin.

Retinal

In Skincare: Is Retinal Safe? Comedogenic Rating & Side Effects

Safety (overall safety)
3/5 — Moderate risk
Irritancy (skin irritation)
4/5 — High risk

Safety Information

Retinaldehyde (vitamin A derivative) can cause irritation, particularly at higher concentrations. The Cosmetic Ingredient Review (CIR) Expert Panel has noted that retinaldehyde may cause ocular and dermal irritation, and it is recommended to conduct patch testing prior to use.

Quick Insights

At a glance

  • 01

    Retinal is also known as retinaldehyde.

  • 02

    As a direct precursor to retinoic acid, retinal works to address signs of aging.

  • 03

    Retinal can help improve the appearance of skin that is prone to blemishes.

  • 04

    Retinal helps minimize the visible signs of fine lines and wrinkles.

  • 05

    Compared to pure retinol, retinal requires one less conversion step within the skin to become its active form.

  • 06

    Retinal is generally well-tolerated, and in some instances may be even better tolerated than pure retinol.

Key Benefits

What Retinal does for your skin

3 benefits
Anti-Aging
Evens Skin Tone
Oil Control

Overview

Ingredient Profile

Retinal is a vitamin A derivative that directly converts to retinoic acid, the active form responsible for various skincare benefits. Research supports its ability to visibly improve signs of aging like fine lines, wrinkles, and hyperpigmentation, while also addressing blemishes by helping to regulate skin bacteria. Studies suggest retinal is well-tolerated and can effectively improve skin texture and tone, even at low concentrations; however, it should be avoided during pregnancy due to its connection to prescription retinoids.
Classifications
Antioxidant
Retinoids

Role of Retinal

Active Cosmetic Mechanisms

SKIN CONDITIONING

Skin Enhancer

Maintains skin in good condition and improves its feel

SCIENTIFIC ANALYSIS

// Evidence: Skin conditioning ingredients enhance appearance, texture, and health of skin through various mechanisms. This broad category encompasses emollients, humectants, occlusives, and other agents that improve skin feel, appearance, and function. May work by moisturizing, smoothing, softening, or protecting skin. Effects include improved tactile properties, enhanced barrier function, and better overall skin condition.

Products

containing Retinal

274 formulations
Cleanance Smoothing Night Cream
Cleanance Smoothing Night Cream
Avène · moisturizer
RetrinAL+ 0.05
RetrinAL+ 0.05
Avène · serums-treatment
Azelac Moisturizing Gel
Azelac Moisturizing Gel
Sesderma · moisturizer

References

Scientific sources

[1]

Dermatology, August 2002, pages 153–158

[2]

Journal of Cosmetic Dermatology, November 2021, pages 3,586-3,592

[3]

Journal of Cosmetic Dermatology, September 2021, pages 2,874-2,879

[4]

Cells, December 2020, pages 1-14

[5]

Journal of Cosmetic Dermatology, January 2018, pages 471-475

[6]

Global Dermatology, January 2016, pages 232-236

[7]

Dermatology, September 2013, pages 231–237

[8]

Journal Der Deutschen Dermatologischen Gesellschaft, December 2008, pages 1,023-1,031

[9]

Dermatology, 1999, pages 57-60

[10]

Dermatology, 1999, pages 29-31

Semantic Analysis

Similar Ingredients

Ingredients with similar chemical profiles and skincare properties.

Frequently Asked Questions

Retinal — common questions

What is Retinal in skincare?

Retinal is a skincare ingredient commonly used in cosmetic formulations.

What does Retinal do? / Functions of Retinal?

Common functions: SKIN CONDITIONING.

What is the comedogenic rating of Retinal? / Is Retinal comedogenic?

The comedogenic rating of Retinal has not been established in our database.

Does it clog pores?
No Rating Available

Whether Retinal clogs pores depends on the formulation and concentration.

Is Retinal safe for skin?
3 3/5 — Moderate risk

Retinal has a safety rating of 3 out of 5. A rating of 3 indicates moderate safety considerations. Note: Retinaldehyde (vitamin A derivative) can cause irritation, particularly at higher concentrations. The Cosmetic Ingredient Review (CIR) Expert Panel has noted that retinaldehyde may cause ocular and de

Is Retinal good for sensitive skin?
4 4/5 — High risk

Retinal has an irritancy rating of 4 out of 5. A rating of 4 means it has high irritation potential.

What are the side effects of Retinal in skincare?

Known considerations: Retinaldehyde (vitamin A derivative) can cause irritation, particularly at higher concentrations. The Cosmetic Ingredient Review (CIR) Expert Panel has noted that retinaldehyde may cause ocular and dermal irritation, and it is recommended to conduct patch testing prior to use. Additional risks: skin irritation (irritancy rating 4/5).

)