What are the key ingredients in C & E Serum Advance+?

C & E Serum Advance+ contains 11 ingredients. Key actives include: Water, Propylene Glycol, Ascorbic Acid, Alcohol Denat., Hyaluronic Acid, and more.

Does C & E Serum Advance+ contain comedogenic or pore-clogging ingredients?

C & E Serum Advance+ contains potentially comedogenic or irritating ingredients: Alcohol Denat.. Always patch test before full use.

How is the safety of C & E Serum Advance+ rated?

Safety ratings for C & E Serum Advance+ are calculated based on individual ingredient analysis, covering comedogenicity, irritancy, and overall safety scores. See the full breakdown at https://www.skinwis.com/product/is-clinical-c-e-serum-advance.

Where can I find the full ingredient list for C & E Serum Advance+?

The complete ingredient list, safety analysis, and community reviews for C & E Serum Advance+ are available on SkinWis at https://www.skinwis.com/product/is-clinical-c-e-serum-advance.

Brand iS Clinical

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C & E Serum Advance+

Updated on: 06/07/2025

Total Ingredients

analysed

7 of 11

Skin-Safe

low risk

1 of 11

Potential Irritants

may irritate sensitive skin

1 of 11

Potential Pore-Clogging

comedogenic risk

About this product

11 ingredients

1 potential irritant

1 pore-clogging

Contains Vitamin C and Vitamin C. Mostly fragrance‑free. Formula aimed at skin types that tolerate moderate comedogenic ingredients. Patch-test if you have very reactive skin.

Formulation Analysis

Click any ingredient to view full details

C: Comedogenic·S: Safety·Ir: Irritancy

1 Very safe

2 Safe

3 Moderate

4 Risky

5 Avoid

C: Comedogenic·S: Safety·Ir: Irritancy

1 Very safe

2 Safe

3 Moderate

4 Risky

5 Avoid

Water

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Very low risk

Plaque Prevention Agent Skin Enhancer Ingredient Dissolver

Propylene Glycol

Comedogenic: Very low risk

Safety: Low risk

Irritancy: Moderate risk

General Skin Improver Moisture Magnet Thickness Regulator +3

Ascorbic Acid

Comedogenic: Very low risk

Safety: Low risk

Irritancy: Moderate risk

Anti-Aging Protector Skin Enhancer pH Stabilizer +1

Alcohol Denat.

Comedogenic: Very low risk

Safety: Moderate risk

Irritancy: High risk

Thickness Regulator Germ Fighter Ingredient Dissolver +3

Hyaluronic Acid

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Very low risk

Skin Enhancer Moisture Magnet Static Eliminator +1

Laureth-4

Comedogenic: High risk

Safety: Moderate risk

Irritancy: Moderate risk

Cleansing Surfactant Static Eliminator Scent Provider +1

Zinc Sulfate

Safety: Low risk

Irritancy: Moderate risk

Plaque Prevention Agent Germ Fighter Pore Tightener +1

Tocopherol

Comedogenic: Low risk

Safety: Low risk

Irritancy: Low risk

General Skin Improver Moisture Barrier Creator Anti-Aging Protector +1

Phenoxyethanol

Safety: Low risk

Irritancy: Moderate risk

Product Protector Germ Fighter

Vitamin C

Vitamin E

Ingredient Name	Safety Profile	Functionality
01 Water	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Plaque Prevention Agent Skin Enhancer +1
02 Propylene Glycol	C 1 Comedogenic: Very low risk S 2 Safety: Low risk Ir 3 Irritancy: Moderate risk	General Skin Improver Moisture Magnet +4
03 Ascorbic Acid	C 1 Comedogenic: Very low risk S 2 Safety: Low risk Ir 3 Irritancy: Moderate risk	Anti-Aging Protector Skin Enhancer +2
04 Alcohol Denat.	C 1 Comedogenic: Very low risk S 3 Safety: Moderate risk Ir 4 Irritancy: High risk	Thickness Regulator Germ Fighter +4
05 Hyaluronic Acid	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Skin Enhancer Moisture Magnet +2
06 Laureth-4	C 4 Comedogenic: High risk S 3 Safety: Moderate risk Ir 3 Irritancy: Moderate risk	Cleansing Surfactant Static Eliminator +2
07 Zinc Sulfate	S 2 Safety: Low risk Ir 3 Irritancy: Moderate risk	Plaque Prevention Agent Germ Fighter +2
08 Tocopherol	C 2 Comedogenic: Low risk S 2 Safety: Low risk Ir 2 Irritancy: Low risk	General Skin Improver Moisture Barrier Creator +2
09 Phenoxyethanol	S 2 Safety: Low risk Ir 3 Irritancy: Moderate risk	Product Protector Germ Fighter
10 Vitamin C		N/A
11 Vitamin E		N/A

Potential Irritants

1 flagged

Alcohol Denat.

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Common Questions

Frequently Asked Questions

Is iS Clinical C & E Serum Advance+ comedogenic?

Appears To Be Comedogenic C & E Serum Advance+ appears to be comedogenic. It contains 1 ingredient with a high comedogenic rating (4–5) that are likely to clog pores , including <a href="/ingredient/laureth-4" class="font-bold underline hover:text-cyan-700">Laureth-4</a> . It may not be suitable for acne-prone skin.

Is iS Clinical a good skincare brand?

US professional skincare brand focusing on anti-aging and clinical results. iS Clinical makes products such as C & E Serum Advance+ that include some ingredients which may be problematic for sensitive or acne-prone skin. Check individual product ingredient lists and community reviews before deciding. Read more about iS Clinical.

Is iS Clinical C & E Serum Advance+ safe for sensitive skin?

Use with Caution C & E Serum Advance+ may not be ideal for sensitive skin. It contains 1 potential irritant including <a href="/ingredient/alcohol-denat-" class="font-bold underline hover:text-cyan-700">Alcohol Denat.</a> . Common triggers like Fragrance, Limonene, and Linalool can cause redness or reactions in sensitive or barrier-compromised skin. We recommend patch testing before full use.

Does iS Clinical C & E Serum Advance+ clog pores?

Potential Pore-Cloggers Present C & E Serum Advance+ contains 1 ingredient with a comedogenic rating of 3 or higher that may clog pores , including <a href="/ingredient/laureth-4" class="font-bold underline hover:text-cyan-700">Laureth-4</a> . Every ingredient's comedogenic rating is listed above.

Who makes iS Clinical C & E Serum Advance+?

This product is from iS Clinical. See more products from iS Clinical.

What are the ingredients in iS Clinical C & E Serum Advance+?

C & E Serum Advance+ contains 11 ingredients. The first ingredients listed are <a href="/ingredient/water" class="font-bold underline hover:text-cyan-700">Water</a>, <a href="/ingredient/propylene-glycol" class="font-bold underline hover:text-cyan-700">Propylene Glycol</a>, <a href="/ingredient/ascorbic-acid" class="font-bold underline hover:text-cyan-700">Ascorbic Acid</a>, <a href="/ingredient/alcohol-denat-" class="font-bold underline hover:text-cyan-700">Alcohol Denat.</a> and <a href="/ingredient/hyaluronic-acid" class="font-bold underline hover:text-cyan-700">Hyaluronic Acid</a>. Each ingredient includes a comedogenic rating, irritancy rating, and safety score. View the full annotated ingredient list above.

What do users say about iS Clinical C & E Serum Advance+?

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Cross-Reference Data