What are the key ingredients in Neuropeptide Necolletage?

Neuropeptide Necolletage contains 32 ingredients. Key actives include: Water, Tetrahexyldecyl Ascorbate, Glycerin, Taurine, Peg-12, and more.

Does Neuropeptide Necolletage contain comedogenic or pore-clogging ingredients?

Neuropeptide Necolletage contains potentially comedogenic or irritating ingredients: Benzyl Alcohol, Parfum. Always patch test before full use.

How is the safety of Neuropeptide Necolletage rated?

Safety ratings for Neuropeptide Necolletage are calculated based on individual ingredient analysis, covering comedogenicity, irritancy, and overall safety scores. See the full breakdown at https://www.skinwis.com/product/perricone-md-neuropeptide-necolletage.

Where can I find the full ingredient list for Neuropeptide Necolletage?

The complete ingredient list, safety analysis, and community reviews for Neuropeptide Necolletage are available on SkinWis at https://www.skinwis.com/product/perricone-md-neuropeptide-necolletage.

Brand Perricone MD

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Neuropeptide Necolletage

Updated on: 10/11/2025

Total Ingredients

analysed

22 of 32

Skin-Safe

low risk

1 of 32

Potential Irritants

may irritate sensitive skin

0 of 32

Potential Pore-Clogging

comedogenic risk

About this product

32 ingredients

1 potential irritant

none pore-clogging

Contains Vitamin C and Peptides. Contains fragrance — patch test if sensitive. Formula aimed at oily and acne-prone skin. Patch-test if you have very reactive skin.

Formulation Analysis

Click any ingredient to view full details

C: Comedogenic·S: Safety·Ir: Irritancy

1 Very safe

2 Safe

3 Moderate

4 Risky

5 Avoid

C: Comedogenic·S: Safety·Ir: Irritancy

1 Very safe

2 Safe

3 Moderate

4 Risky

5 Avoid

Water

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Very low risk

Plaque Prevention Agent Skin Enhancer Ingredient Dissolver

Tetrahexyldecyl Ascorbate

Glycerin

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Very low risk

Fragrance Provider Moisture Magnet Thickness Regulator +7

Taurine

Safety: Very low risk

Irritancy: Very low risk

pH Stabilizer

Peg-12

Safety: Low risk

Irritancy: Low risk

Moisture Magnet Ingredient Dissolver

Carbomer

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Very low risk

Gel Structure Builder Thickness Regulator Emulsion Stabilizer

Tyrosine

Safety: Very low risk

Irritancy: Very low risk

Skin Enhancer Static Eliminator Hair Softener +1

Hydroxylated Lecithin

Safety: Low risk

Cleansing Surfactant Skin Enhancer Emulsifying Surfactant

Butylene Glycol

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Low risk

Skin Enhancer Moisture Magnet Thickness Regulator +2

Safety: Moderate risk

Irritancy: Moderate risk

Product Protector Fragrance Provider Thickness Regulator +1

Phosphatidylcholine

Comedogenic: Very low risk

Safety: Very low risk

Irritancy: Very low risk

Skin Enhancer Emulsifying Surfactant

Magnesium Ascorbyl Phosphate

Safety: Very low risk

Irritancy: Very low risk

Anti-Aging Protector Skin Enhancer

Sodium fumarate

pH Stabilizer

Phytic Acid

Safety: Low risk

Irritancy: Low risk

Metal Ion Binder

Pantethine

Hair Softener Skin Softener

Glycyrrhetinic Acid

Safety: Low risk

Irritancy: Low risk

Skin Enhancer

Parfum

Safety: Moderate risk

Irritancy: High risk

Fragrance Provider Scent Provider

Ascorbyl Palmitate

Comedogenic: Low risk

Safety: Low risk

Irritancy: Very low risk

Anti-Aging Protector Scent Provider

Carnosine

Safety: Very low risk

Irritancy: Very low risk

Skin Enhancer

Ferulic Acid

Safety: Low risk

Irritancy: Low risk

Anti-Aging Protector Germ Fighter

Docosahexaenoic Acid

Safety: Low risk

Irritancy: Low risk

Skin Enhancer Static Eliminator

Zinc Gluconate

Safety: Low risk

Irritancy: Very low risk

Skin Enhancer Germ Fighter Odor Neutralizer +1

Magnesium Aspartate

Safety: Low risk

Skin Enhancer

Polysorbate 20

Comedogenic: Very low risk

Safety: Low risk

Irritancy: Low risk

Cleansing Surfactant Emulsifying Surfactant

Palmitoyl Oligopeptide

Safety: Low risk

Irritancy: Very low risk

Cleansing Surfactant Skin Enhancer Dirt & Oil Remover

Copper Gluconate

Safety: Low risk

Irritancy: Low risk

Skin Enhancer Defensive Shield

Elaeis guineensis extract

Safety: Low risk

Skin Enhancer Moisture Magnet

Derivative of vitamin C

Ingredient Name	Safety Profile	Functionality
01 Water	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Plaque Prevention Agent Skin Enhancer +1
02 Tetrahexyldecyl Ascorbate		N/A
03 Glycerin	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Fragrance Provider Moisture Magnet +8
04 Taurine	S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	pH Stabilizer
05 Peg-12	S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Moisture Magnet Ingredient Dissolver
06 Carbomer	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Gel Structure Builder Thickness Regulator +1
07 Tyrosine	S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Skin Enhancer Static Eliminator +2
08 Hydroxylated Lecithin	S 2 Safety: Low risk	Cleansing Surfactant Skin Enhancer +1
09 Butylene Glycol	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 2 Irritancy: Low risk	Skin Enhancer Moisture Magnet +3
10 Dimethyl Mea		pH Stabilizer
11 Acetyl carnosine		Defensive Shield
12 Benzyl Alcohol	S 3 Safety: Moderate risk Ir 3 Irritancy: Moderate risk	Product Protector Fragrance Provider +2
13 Phosphatidylcholine	C 1 Comedogenic: Very low risk S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Skin Enhancer Emulsifying Surfactant
14 Magnesium Ascorbyl Phosphate	S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Anti-Aging Protector Skin Enhancer
15 Sodium fumarate		pH Stabilizer
16 Phytic Acid	S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Metal Ion Binder
17 Pantethine		Hair Softener Skin Softener
18 Glycyrrhetinic Acid	S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Skin Enhancer
19 Parfum	S 3 Safety: Moderate risk Ir 4 Irritancy: High risk	Fragrance Provider Scent Provider
20 Ascorbyl Palmitate	C 2 Comedogenic: Low risk S 2 Safety: Low risk Ir 1 Irritancy: Very low risk	Anti-Aging Protector Scent Provider
21 Carnosine	S 1 Safety: Very low risk Ir 1 Irritancy: Very low risk	Skin Enhancer
22 Ferulic Acid	S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Anti-Aging Protector Germ Fighter
23 Docosahexaenoic Acid	S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Skin Enhancer Static Eliminator
24 Zinc Gluconate	S 2 Safety: Low risk Ir 1 Irritancy: Very low risk	Skin Enhancer Germ Fighter +2
25 Magnesium Aspartate	S 2 Safety: Low risk	Skin Enhancer
26 Polysorbate 20	C 1 Comedogenic: Very low risk S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Cleansing Surfactant Emulsifying Surfactant
27 Palmitoyl Oligopeptide	S 2 Safety: Low risk Ir 1 Irritancy: Very low risk	Cleansing Surfactant Skin Enhancer +1
28 Copper Gluconate	S 2 Safety: Low risk Ir 2 Irritancy: Low risk	Skin Enhancer Defensive Shield
29 Elaeis guineensis extract		Skin Enhancer
30 Tetrapeptide-3		Skin Enhancer
31 Acetyl Hexapeptide-8	S 2 Safety: Low risk	Skin Enhancer Moisture Magnet
32 Derivative of vitamin C		N/A

Potential Irritants

2 flagged

Benzyl Alcohol Parfum

Community

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Common Questions

Frequently Asked Questions

Is Perricone MD Neuropeptide Necolletage comedogenic?

Appears Non-Comedogenic Neuropeptide Necolletage appears to be non-comedogenic based on our ingredient analysis. None of its 32 ingredients carry a high comedogenic rating, making it generally suitable for acne-prone and oily skin types.

Is Perricone MD a good skincare brand?

Perricone MD is a US clinical skincare brand founded by Dr. Nicholas Perricone. It focuses on anti-aging treatments with ingredients like DMAE, alpha lipoic acid, and vitamins for skin health. Perricone MD makes products such as Neuropeptide Necolletage that include some ingredients which may be problematic for sensitive or acne-prone skin. Check individual product ingredient lists and community reviews before deciding. Read more about Perricone MD.

Is Perricone MD Neuropeptide Necolletage safe for sensitive skin?

Use with Caution Neuropeptide Necolletage may not be ideal for sensitive skin. It contains 2 potential irritant s including <a href="/ingredient/parfum" class="font-bold underline hover:text-cyan-700">Parfum</a> and <a href="/ingredient/benzyl-alcohol" class="font-bold underline hover:text-cyan-700">Benzyl Alcohol</a> . Common triggers like Fragrance, Limonene, and Linalool can cause redness or reactions in sensitive or barrier-compromised skin. We recommend patch testing before full use.

Does Perricone MD Neuropeptide Necolletage clog pores?

Unlikely to Clog Pores Based on our analysis, Neuropeptide Necolletage is unlikely to clog pores. None of its 32 ingredients have a comedogenic rating above 2.

Who makes Perricone MD Neuropeptide Necolletage?

This product is from Perricone MD. See more products from Perricone MD.

What are the ingredients in Perricone MD Neuropeptide Necolletage?

Neuropeptide Necolletage contains 32 ingredients. The first ingredients listed are <a href="/ingredient/water" class="font-bold underline hover:text-cyan-700">Water</a>, <a href="/ingredient/tetrahexyldecyl-ascorbate" class="font-bold underline hover:text-cyan-700">Tetrahexyldecyl Ascorbate</a>, <a href="/ingredient/glycerin" class="font-bold underline hover:text-cyan-700">Glycerin</a>, <a href="/ingredient/taurine" class="font-bold underline hover:text-cyan-700">Taurine</a> and <a href="/ingredient/peg-12" class="font-bold underline hover:text-cyan-700">Peg-12</a>. Each ingredient includes a comedogenic rating, irritancy rating, and safety score. View the full annotated ingredient list above.

What do users say about Perricone MD Neuropeptide Necolletage?

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Cross-Reference Data